Vayne vs Annie — Top Lane Matchup Guide
You
Vayne
Opponent
Annie
Your ranked stats
50.0%
Win rate
8.0%
Pick rate
11.0%
Ban rate
1.83
KDA
B
Tier
#65
Rank
Opponent stats
51.0%
Win rate
3.0%
Pick rate
1.0%
Ban rate
2.17
KDA
C
Tier
#126
Rank
A level-by-level game plan for Vayne vs Annie.
Levels 1-2
Lane priority is decided by who wins the level 1-2 skirmish or poke exchange.
- Vayne is weak early — focus on last-hitting safely and avoid unnecessary exchanges.
- Annie likely outranges you — approach through minion wave cover instead of walking in.
- OP.GG data flags Vayne as a strong counter to Annie in this role — you can afford to lean into trades early.
Levels 3-5
Trading windows open as skills come online — track cooldowns before you commit.
- Auto-attack trades start favoring you as attack speed and items come online.
- Expect poke whenever you're out of position; punish only after they use their combo.
Level 6
Ultimates come online. This is usually the first real all-in window of the lane.
- Depending on your kit this is either a power spike or just more survivability — play accordingly.
- Their ultimate usually adds burst or CC — don't sit still in their range once it's up.
Levels 7-11
Priority shifts toward objectives — use a lane lead to pressure river, dragon, or Herald.
- Positioning in skirmishes matters as much as damage — never be the first one hit.
- Watch for wave clear into a fast roam — don't get caught alone in a side lane.
Levels 12-15
Item spikes start deciding fights more than levels do.
- Your crit or on-hit spike should make you the biggest DPS threat in every fight.
- Burst items make them a one-combo kill threat on squishies — use minions or terrain as cover.
Level 16+
Both ultimates are maxed — play for your team's win condition, not just the lane.
- You're the primary win condition in teamfights — kiting and positioning decide the game.
- Focus them first in teamfights if you can reach them — they melt fast but hit hard if ignored.
OP.GG data as of Jul 13, 2026 · patch 16.13.1