Annie vs Vayne — Top Lane Matchup Guide
You
Annie
Opponent
Vayne
Your ranked stats
51.0%
Win rate
3.0%
Pick rate
1.0%
Ban rate
2.17
KDA
C
Tier
#126
Rank
Opponent stats
50.0%
Win rate
8.0%
Pick rate
11.0%
Ban rate
1.83
KDA
B
Tier
#65
Rank
A level-by-level game plan for Annie vs Vayne.
Levels 1-2
Lane priority is decided by who wins the level 1-2 skirmish or poke exchange.
- Annie should poke with your range advantage and avoid trading autos in melee range.
- Vayne is weak early — this is your best window to apply pressure before items come online.
- OP.GG data flags Vayne as a strong counter to Annie in this role — expect them to look for early trades, so play a touch safer than usual.
Levels 3-5
Trading windows open as skills come online — track cooldowns before you commit.
- Farm from range and punish any hard engage with your full combo before they close the gap.
- Their auto-attack trades start improving — don't stand and trade without an advantage.
Level 6
Ultimates come online. This is usually the first real all-in window of the lane.
- Your ultimate usually adds burst or CC that turns pokes into kills — look for the window.
- Not always a big spike for this class — check their item progress rather than just level.
Levels 7-11
Priority shifts toward objectives — use a lane lead to pressure river, dragon, or Herald.
- Wave clear lets you control the lane state; push to roam or freeze to bait a dive.
- In skirmishes, look to dive them first — removing their damage usually decides the fight.
Levels 12-15
Item spikes start deciding fights more than levels do.
- Your core item spikes here — you should threaten kills from well outside melee range.
- Once crit or on-hit items complete they out-damage most champions in long fights.
Level 16+
Both ultimates are maxed — play for your team's win condition, not just the lane.
- You're a primary damage source from range — play from the back and burst priority targets.
- They're the other team's win condition — focus them or block line of sight in every fight.
OP.GG data as of Jul 13, 2026 · patch 16.13.1